Neurobiology of Disease Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson’s Disease
نویسندگان
چکیده
Matteo Marti,1 Flora Mela,1 Martina Fantin,1 Silvia Zucchini,1 Jeffrey M. Brown,4 Jassir Witta,4 Manuela Di Benedetto,3 Beata Buzas,4 Rainer K. Reinscheid,5 Severo Salvadori,2 Remo Guerrini,2 Patrizia Romualdi,3 Sanzio Candeletti,3 Michele Simonato,1 Brian M. Cox,4 and Michele Morari1 1Department of Experimental and Clinical Medicine, Section of Pharmacology, and Neuroscience Center, and 2Department of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, 44100 Ferrara, Italy, 3Department of Pharmacology, University of Bologna, 40126 Bologna, Italy, 4Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, and 5Department of Pharmacology, University of California, Irvine, Irvine, California 92697
منابع مشابه
Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.
Endogenous nociceptin/orphanin FQ (N/OFQ) inhibits the activity of dopamine neurons in the substantia nigra and affects motor behavior. In this study we investigated whether a N/OFQ receptor (NOP) antagonist, J-113397, can modify movement in naive mice and nonhuman primates and attenuate motor deficits in MPTP-treated parkinsonian animals. J-113397 facilitated motor activity in naïve mice at lo...
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The present study investigated the modulatory actions of nociceptin/orphanin FQ on excitatory glutamatergic transmission in spinal dorsal horn. In transverse spinal cord slices with an attached dorsal root, mono- and polysynaptic A delta-fibre-evoked extracellular field potentials were recorded from superficial dorsal horn. Nociceptin/orphanin FQ showed bidirectional effects on monosynaptic tra...
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Nociceptin/orphanin FQ and nocistatin are two neuropeptides with opposing effects on spinal neurotransmission and nociception. Nociceptin/orphanin FQ selectively suppresses excitatory glutamatergic neurotransmission, while nocistatin selectively interferes with glycinergic and gamma-aminobutyric acid (GABA)-ergic transmission. Here, we performed whole-cell patch-clamp recordings from superficia...
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δ opioid peptide (DOP) receptors are considered a therapeutic target in Parkinson's disease, although the use of DOP agonists may be limited by side effects, including convulsions. To circumvent this issue, we evaluated whether blockade of nociceptin/orphanin FQ (N/OFQ) tone potentiated the antiparkinsonian effects of DOP agonists, thus allowing for reduction of their dosage. Systemic administr...
متن کاملParkinson’s disease: no NOP, new hope
Nociceptin/orphanin FQ (henceforth N/OFQ) is the endogenous ligand of the so-called nociceptin opioid peptide (NOP) receptor, a.k.a. Opioid Receptor Like 1 (ORL1) receptor, a G-protein coupled receptor which couples to Gi/o and intracellular kinases, among which mitogen-activated protein (MAP) kinases [1]. In 2004, we provided the first evidence that N/OFQ might play a role in Parkinson's disea...
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